The Weber Light Letter: Issue No. 5

The Weber Light Letter: Issue No. 5

The Weber Light Letter

From studies to practice: The latest in tPBM and laser therapy for clinicians.

Photobiomodulation | Research | Clinical Practice

Subscribe: The Weber Light Letter

A New Benchmark in Brain PBM Research

A major 2025 study (Li et al., PLOS Biology) used RNA sequencing to observe how 808 nm tPBM affects gene expression in the cortex and hippocampus.

In just 20 minutes, hundreds of genes changed — including those tied to:

  • Mitochondrial function
  • Inflammation
  • Oxidative stress response
  • Alzheimer’s pathways

Key effects included upregulation of BDNF, SOD, and Aβ clearance genes, and suppression of TNF-α and β-secretase.

Why it matters: this is one of the clearest molecular-level validations yet that light doesn’t just enter, it alters.

Live from Scottsdale: Integrative Oncology 2025

This weekend, the Weber Medical Systems team is on-site at the 18th International Conference on Integrative Oncology in Scottsdale, Arizona. We’re proud to be an official conference partner, sharing how laser-based photobiomodulation can support cancer care, from patient fatigue and recovery to immune modulation and long-term wellness.

If you're attending, stop by our booth. We'd love to connect.

Framework Spotlight: The 3-Layer Model of tPBM

Light therapy isn’t just about power — it’s about precision. At Weber, we organize tPBM by depth and biological effect:

  • 680 nm (Red Light): Surface & skin-adjacent neurons
  • 808 nm (Near-Infrared): Blood flow, oxygenation
  • 1064 nm (Infrared): Deep cortex & subcortical regions

 

Each layer activates different pathways, and together they form a therapeutic cascade from surface to hippocampus.

This is why the WeberBrain includes all three.

Article content

Inside WeberBrain: Built for Scale

As demand grows, clinical scalability matters more than ever.

From day one, the WeberBrain was built with multi-user clinics in mind:

  • Hygienic design with UV-compatible, sterilizable parts
  • Replaceable caps and components for patient-to-patient rotation
  • Durable, low-maintenance engineering for high-throughput environments

 

Every detail, from spring-loaded contact points to modular hexes  supports consistency, cleanliness, and outcomes.

Thanks for being part of this movement.

The science is moving fast  and with each trial, patient, and protocol, light moves closer to the standard of care.

Until next time,

Stay bright - Robert

Source & credit: Weber Medical

Back to blog

Leave a comment